Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869691 | 0.92 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL8869973 | 0.90 | CYP1A2 (0.46) | SMN1; SMN2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL8870073 | 0.89 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL8869173 | 0.89 | POLB (0.42) | SMN1; SMN2LMNAPKM | |
| SCHEMBL8868341 | 0.84 | CYP1A2 (0.45) | SMN1; SMN2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL8867662 | 0.82 | SCN9A (0.48) | SMN1; SMN2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL8868644 | 0.81 | HTT (0.53) | HTTLMNAMAPT | |
| SCHEMBL8869067 | 0.80 | PGR (0.53) | CYP3A4CYP2C9CYP2C19LMNACCR2 | |
| SCHEMBL8870156 | 0.80 | P4HTM (0.51) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL8868611 | 0.79 | EGLN1 (0.46) | SMN1; SMN2CYP3A4CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |