Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869556 | 0.91 | POLB (0.45) | POLBKDM4ESMN1; SMN2LMNAPKM | |
| SCHEMBL8869691 | 0.90 | SMN1; SMN2 (0.44) | POLBKDM4ESMN1; SMN2LMNAPKM | |
| SCHEMBL8868415 | 0.89 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAPKM | |
| SCHEMBL8869937 | 0.86 | P4HTM (0.52) | POLBSMN1; SMN2 | |
| SCHEMBL8870073 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8869163 | 0.84 | POLB (0.47) | POLBLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8868611 | 0.82 | EGLN1 (0.46) | POLBSMN1; SMN2EGLN1 | |
| SCHEMBL8867662 | 0.80 | SCN9A (0.48) | KDM4ESMN1; SMN2LMNAPKMMEN1 | |
| SCHEMBL9574660 | 0.79 | SMN1; SMN2 (0.42) | POLBKDM4ESMN1; SMN2LMNAPKM | |
| SCHEMBL8869647 | 0.79 | PGR (0.50) | POLBSMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |