Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 2/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869383 | 0.84 | P4HTM (0.46) | EGLN1PRKAA2P4HTMALDH1A1RAB9A | |
| SCHEMBL8869722 | 0.84 | CXCR1 (0.44) | CXCR1CXCR2PRKAA2P4HTMALDH1A1 | |
| SCHEMBL8869725 | 0.83 | P4HTM (0.39) | CXCR1CXCR2EGLN1PRKAA2P4HTM | |
| SCHEMBL8870011 | 0.81 | PRKAA2 (0.45) | PRKAA2P4HTMALDH1A1KDM4EPOLB | |
| SCHEMBL8867749 | 0.81 | P4HTM (0.48) | CXCR1CXCR2PRKAA2P4HTMALDH1A1 | |
| SCHEMBL8869212 | 0.80 | RAB9A (0.48) | PRKAA2P4HTMALDH1A1KDM4EPOLB | |
| SCHEMBL9143213 | 0.77 | MAPK1 (0.48) | CXCR1CXCR2PRKAA2P4HTMALDH1A1 | |
| SCHEMBL8867850 | 0.76 | P4HTM (0.54) | EGLN1P4HTMALDH1A1KDM4ERAB9A | |
| SCHEMBL9137956 | 0.75 | P4HTM (0.43) | CXCR1CXCR2PRKAA2P4HTMALDH1A1 | |
| SCHEMBL9144590 | 0.75 | P4HTM (0.43) | CXCR1CXCR2P4HTMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |