Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9137949 | 0.89 | CXCR1 (0.45) | CXCR1CXCR2POLBP4HTMRAB9A | |
| SCHEMBL8869725 | 0.88 | P4HTM (0.39) | CXCR1CXCR2POLBKMT2AP4HTM | |
| SCHEMBL8867749 | 0.88 | P4HTM (0.48) | CXCR1CXCR2KMT2AP4HTMSMN1; SMN2 | |
| SCHEMBL8869383 | 0.88 | P4HTM (0.46) | P4HTMRAB9AALDH1A1PRKAA2 | |
| SCHEMBL8869212 | 0.85 | RAB9A (0.48) | POLBKMT2AP4HTMRAB9ANPC1 | |
| SCHEMBL8870011 | 0.84 | PRKAA2 (0.45) | POLBKMT2AP4HTMRAB9AALDH1A1 | |
| SCHEMBL8868451 | 0.84 | CXCR1 (0.46) | CXCR1CXCR2POLBP4HTMRAB9A | |
| SCHEMBL8867821 | 0.84 | CXCR1 (0.40) | CXCR1CXCR2POLBKMT2AP4HTM | |
| SCHEMBL8870177 | 0.84 | KMT2A (0.46) | POLBKMT2AP4HTMRAB9ANPC1 | |
| SCHEMBL8869086 | 0.84 | P4HTM (0.45) | POLBP4HTMMMP1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |