SCHEMBL886859

SCHEMBL886859

C#CC[C@]1(n2cc(N)c(N)nc2=O)C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
POLG P54098 2/20 0.41
P2RY2 P41231 7/20 0.39
P2RY6 Q15077 3/20 0.39
P2RY4 P51582 3/20 0.39
P2RX1 P51575 4/20 0.36
P2RX3 P56373 4/20 0.36
P2RX2 Q9UBL9 1/20 0.36
P2RX4 Q99571 3/20 0.36
ENPP1 P22413 1/20 0.36
P2RY1 P47900 1/20 0.36
P2RY11 Q96G91 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27186873 0.87 POLG (0.41) POLGP2RY2P2RY6P2RY4P2RX1
SCHEMBL5708922 0.86 POLG (0.48) POLGP2RY2P2RY6P2RY4
SCHEMBL3485976 0.85 P2RY6 (0.41) P2RY2P2RY6P2RY4P2RX3
SCHEMBL6511718 0.84 P2RY2 (0.41) POLGP2RY2P2RY6P2RY4P2RX1
SCHEMBL5500343 0.81 DNMT1 (0.33)
SCHEMBL31166285 0.77 POLG (0.43) POLGP2RY2P2RY6P2RY4P2RX1
SCHEMBL6038233 0.77 POLG (0.50) POLGP2RY2P2RY6P2RY4
SCHEMBL7520080 0.76 P2RY2 (0.35) P2RY2P2RY6P2RY4P2RX1P2RX3
SCHEMBL10900419 0.75 POLG (0.49) POLGP2RY2P2RY6P2RY4
SCHEMBL597307 0.75 POLG (0.49) POLGP2RY2P2RY6P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050214759-A1 Enzymatic redox labelling of nucleic acids WLASSOF WJATSCHESSLAW 2005-09-29 US claimed
EP-1725572-B1 MACROMOLECULAR NUCLEOTIDE COMPOUNDS AND METHODS FOR USING THE SAME AGCT GMBH (DE) 2017-05-31 EP disclosed
US-9035035-B2 Macromolecular nucleotide compounds and methods for using the same GENOVOXX GMBH (DE) 2015-05-19 US disclosed
US-20150086981-A1 NUCLEOSIDE-TRIPHOSPHATE CONJUGATE AND METHODS FOR THE USE THEREOF GENOVOXX GMBH (DE) 2015-03-26 US disclosed
US-8637650-B2 Macromolecular nucleotide compounds and methods for using the same GENOVOXX GMBH (DE) 2014-01-28 US disclosed
EP-1430153-B1 METHODS FOR DETECTING GENETIC MOSAICISMS USING ARRAYS PERKINELMER LAS INC (US) 2011-11-16 EP disclosed
US-7994296-B2 Biochip microarray for use in determining the relative amount of biological molecules (nucleic acid sequences) in two or more samples; comparative genomic hybridization PERKINELMER HEALTH SCIENCES, INC. (US) 2011-08-09 US disclosed
US-7943299-B2 Using tumor suppressor protein to identify single nucleotide polymorphisms associated immobilized microarrys sequences EPPENDORF AG (DE) 2011-05-17 US disclosed
US-20100304368-A1 COMPONENTS AND METHOD FOR ENZYMATIC SYNTHESIS OF NUCLEIC ACIDS AGCT GMBH (DE) 2010-12-02 US disclosed
US-20100167953-A1 METHODS AND APPARATUSES FOR COMPARATIVE GENOMIC MICROARRAY ANALYSIS BALLIF BLAKE C 2010-07-01 US disclosed
WO-2003055898-A1 ENZYMATIC REDOX LABELLING OF NUCLEIC ACIDS UNISEARCH LIMITED (AU) 2003-07-10 WO disclosed
US-20030124584-A1 Methods for detecting genetic mosaicisms using arrays SPECTRAL GENOMICS, INC. 2003-07-03 US disclosed
US-20030124542-A1 Microarray for detecting chromatin aberrations; anticarcinogenic agents; antitumor agents; tissue engineering SPECTRAL GENOMICS, INC. 2003-07-03 US disclosed
WO-2003027638-A2 METHODS FOR DETECTING GENETIC MOSAICISMS USING ARRAYS SPECTRAL GENOMICS, INC. (US) 2003-04-03 WO disclosed
WO-2003020898-A2 ARRAYS COMPRISING PRE-LABELED BIOLOGICAL MOLECULES AND METHODS FOR MAKING AND USING THESE ARRAYS SPECTRAL GENOMICS, INC. (US) 2003-03-13 WO disclosed
US-20030003496-A1 Generation of molecular profile of genomic nucleotide sequences; obtain sample nucleotide sequences, incubate with probes, detect, analyze and record hybridization pattern BAYLOR COLLEGE MEDICINE, A TEXAS CORPORATION 2003-01-02 US disclosed
EP-0747448-B1 Rigidized monomethine cyanine dyes UNIV CARNEGIE MELLON (US) 2002-11-06 EP disclosed
US-20020006622-A1 Novel compositions and methods for array-based nucleic acid hybridization NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-01-17 US disclosed
WO-2001094630-A2 COMPOSITIONS AND METHODS FOR ARRAY-BASED NUCLEIC ACID HYBRIDIZATION BAYLOR COLLEGE OF MEDICINE (US) 2001-12-13 WO disclosed
EP-0747448-A2 Rigidized monomethine cyanine dyes CARNEGIE-MELLON UNIVERSITY (US) 1996-12-11 EP disclosed