Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9574741 | 0.93 | LIMK1 (0.40) | LIMK1LIMK2P4HTMEGFRBCL2L1 | |
| SCHEMBL7871612 | 0.92 | LIMK1 (0.41) | LIMK1LIMK2P4HTMEGFRHDAC1 | |
| SCHEMBL7867702 | 0.91 | BCL2L1 (0.37) | LIMK1LIMK2P4HTMBCL2L1MCL1 | |
| SCHEMBL7869442 | 0.87 | EGFR (0.43) | P4HTMEGFRCYP2C9GABRA5 | |
| SCHEMBL9018259 | 0.87 | LIMK1 (0.45) | LIMK1LIMK2P4HTMEGFRBCL2L1 | |
| SCHEMBL8869042 | 0.86 | P4HTM (0.48) | LIMK1LIMK2P4HTMEGFRBCL2L1 | |
| SCHEMBL7862801 | 0.86 | CA2 (0.48) | P4HTMEGFR | |
| SCHEMBL7867912 | 0.85 | EGFR (0.47) | P4HTMEGFREPHX2GABRA5 | |
| SCHEMBL7871570 | 0.84 | EGFR (0.45) | P4HTMEGFROPRK1EPHX2GABRA5 | |
| SCHEMBL7869462 | 0.84 | LIMK2 (0.41) | LIMK1LIMK2P4HTMEGFRBCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |