Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867983 | 0.91 | LMNA (0.47) | SMN1; SMN2TSHRMAPK1LMNACYP3A4 | |
| SCHEMBL9138724 | 0.87 | P4HTM (0.61) | SMN1; SMN2TSHRMAPK1LMNAP4HTM | |
| SCHEMBL8869573 | 0.87 | MAPT (0.56) | SMN1; SMN2TSHRMAPK1LMNACYP3A4 | |
| SCHEMBL7870524 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRMAPK1LMNAMAPT | |
| SCHEMBL9138365 | 0.85 | LMNA (0.52) | SMN1; SMN2TSHRMAPK1LMNAMAPT | |
| SCHEMBL8868071 | 0.84 | LMNA (0.55) | SMN1; SMN2TSHRLMNACYP3A4HTR1A | |
| SCHEMBL8868894 | 0.83 | P4HTM (0.51) | P4HTMALDH1A1MEN1KMT2AEGFR | |
| SCHEMBL8868261 | 0.81 | P4HTM (0.49) | SMN1; SMN2LMNACYP2C9CYP2C19P4HTM | |
| SCHEMBL8869420 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRLMNACYP3A4HTR1A | |
| SCHEMBL8868551 | 0.80 | P4HTM (0.47) | SMN1; SMN2LMNAMAPTCYP2C19P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |