Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17331347 | 0.92 | POLB (0.58) | POLBSMN1; SMN2PKMKDM4EALDH1A1 | |
| SCHEMBL8869314 | 0.91 | POLB (0.55) | POLBSMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL19102218 | 0.85 | POLB (0.59) | POLBPKMKDM4EALDH1A1F2 | |
| SCHEMBL9574871 | 0.85 | CACNA1B (0.48) | SMN1; SMN2PKMKDM4ELMNAHTT | |
| SCHEMBL8869534 | 0.85 | PGR (0.53) | SMN1; SMN2PKMKDM4ELMNAHTT | |
| SCHEMBL17331332 | 0.81 | POLB (0.60) | POLBPKMLMNAALDH1A1F2 | |
| SCHEMBL17347485 | 0.80 | ALDH1A1 (0.50) | POLBSMN1; SMN2PKMKDM4EALDH1A1 | |
| SCHEMBL8868444 | 0.79 | KDR (0.49) | POLBSMN1; SMN2LMNAHTTPGR | |
| SCHEMBL17331327 | 0.79 | POLB (0.58) | POLBSMN1; SMN2PKMKDM4ELMNA | |
| SCHEMBL8868618 | 0.77 | MCL1 (0.51) | MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |