Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 6/20 | 0.53 |
| ▸ | ALKBH2 | Q6NS38 | 5/20 | 0.53 |
| ▸ | ALKBH3 | Q96Q83 | 5/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867785 | 0.90 | ALKBH2 (0.52) | FTOALKBH2ALKBH3ALKBH5SMN1; SMN2 | |
| SCHEMBL8869527 | 0.88 | ALKBH2 (0.54) | FTOALKBH2ALKBH3ALKBH5SMN1; SMN2 | |
| SCHEMBL8870003 | 0.85 | P4HTM (0.56) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL7871560 | 0.78 | MEN1 (0.41) | FTOALKBH2ALKBH3ALKBH5SMN1; SMN2 | |
| SCHEMBL7867676 | 0.77 | EPHX2 (0.42) | FTOALKBH2ALKBH3ALKBH5SMN1; SMN2 | |
| SCHEMBL8869937 | 0.77 | P4HTM (0.52) | SMN1; SMN2NPC1RAB9AP4HTMBCL2L1 | |
| SCHEMBL8869556 | 0.77 | POLB (0.45) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL8868286 | 0.75 | P4HTM (0.55) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL8868423 | 0.74 | ALKBH2 (0.52) | FTOALKBH2ALKBH3ALKBH5ALDH1A1 | |
| SCHEMBL8868467 | 0.74 | P4HTM (0.71) | MEN1KMT2AP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |