Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327128 | 0.88 | MAOB (0.61) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| SCHEMBL9976084 | 0.79 | ACHE (0.68) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| SCHEMBL16736880 | 0.79 | MAPT (0.55) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| SCHEMBL8870443 | 0.78 | MAPT (0.55) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| SCHEMBL11866217 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| SCHEMBL4985779 | 0.77 | MAPT (0.80) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| SCHEMBL8888664 | 0.77 | NPC1 (0.54) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| 6,4'-Dimethoxyflavone SCHEMBL29478471 | 0.75 | MAPT (1.00) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| 6,4'-Dimethoxyflavone SCHEMBL4281291 | 0.75 | MAPT (1.00) | ALDH1A1HPGDKDM4EMAPTNPC1 | |
| SCHEMBL7325075 | 0.75 | TNKS (0.58) | ALDH1A1HPGDKDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607928-A | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives | ZENECA LIMITED (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0695753-A1 | Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use | ZENECA LIMITED (GB) | 1996-02-07 | — | — | EP | disclosed |