SCHEMBL8869909

SCHEMBL8869909

CN(C)CCc1c[nH]c2ccc(Oc3ccccc3)cc12

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 8/20 0.72
TRPM8 Q7Z2W7 2/20 0.72
HTR1B P28222 6/20 0.71
HTR1A P08908 5/20 0.71
HTR2A P28223 2/20 0.71
HTR2C P28335 2/20 0.71
HTR2B P41595 2/20 0.71
HTR6 P50406 2/20 0.71
HTR3E A5X5Y0 1/20 0.71
HTR3B O95264 1/20 0.71
CYP1A2 P05177 1/20 0.71
CYP2D6 P10635 1/20 0.71
CYP2C9 P11712 1/20 0.71
HTR1E P28566 1/20 0.71
HTR1F P30939 1/20 0.71
HTR7 P34969 1/20 0.71
HTR3A P46098 1/20 0.71
HTR5A P47898 1/20 0.71
MTNR1A P48039 1/20 0.71
MTNR1B P49286 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8868914 0.90 HTR1D (0.85) HTR1DTRPM8HTR1BHTR1AHTR2A
SCHEMBL8869593 0.90 HTR1D (0.71) HTR1DTRPM8HTR1BHTR1AHTR2A
SCHEMBL8869175 0.88 HTR1D (0.70) HTR1DTRPM8HTR1BHTR1AHTR2A
SCHEMBL8868834 0.87 HTR1D (0.64) HTR1DTRPM8HTR1BHTR1AHTR2A
Oxalic Acid SCHEMBL8870335 0.86 KMT2A (0.75) HTR1DTRPM8HTR1BHTR1AHTR2A
Oxalic Acid SCHEMBL8869617 0.86 KMT2A (0.87) HTR1DTRPM8HTR1BHTR1AHTR2A
Oxalic Acid SCHEMBL8870089 0.85 KMT2A (0.73) HTR1DTRPM8HTR1BHTR1AHTR2A
SCHEMBL2546728 0.85 HTR6 (0.74) HTR1DTRPM8HTR1BHTR1AHTR2A
SCHEMBL8870467 0.85 HTR1D (0.61) HTR1DTRPM8HTR1BHTR1AHTR2A
SCHEMBL8868344 0.84 HTR1D (0.70) HTR1DTRPM8HTR1BHTR1AHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0674619-A1 TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-10-04 EP claimed
WO-1994014770-A1 TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-07-07 WO claimed
US-5637593-A MIGRAINE; HYPOTENSIVE AGENTS SMITHKLINE BEECHAM PLC (GB) 1997-06-10 US disclosed
EP-0674619-A1 TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-10-04 EP disclosed
WO-1994014770-A1 TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-07-07 WO disclosed