Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.71 |
| ▸ | HTR1B | P28222 | 8/20 | 0.71 |
| ▸ | HTR1A | P08908 | 6/20 | 0.71 |
| ▸ | HTR2A | P28223 | 2/20 | 0.71 |
| ▸ | HTR2C | P28335 | 2/20 | 0.71 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.71 |
| ▸ | HTR3B | O95264 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | HTR1E | P28566 | 1/20 | 0.71 |
| ▸ | HTR1F | P30939 | 1/20 | 0.71 |
| ▸ | HTR7 | P34969 | 1/20 | 0.71 |
| ▸ | HTR2B | P41595 | 1/20 | 0.71 |
| ▸ | HTR3A | P46098 | 1/20 | 0.71 |
| ▸ | HTR5A | P47898 | 1/20 | 0.71 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.71 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.71 |
| ▸ | HTR6 | P50406 | 1/20 | 0.71 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8870335 | 0.93 | KMT2A (0.75) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8869909 | 0.90 | HTR1D (0.72) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8868914 | 0.90 | HTR1D (0.85) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8869175 | 0.88 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8870437 | 0.86 | HTR1D (0.52) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL4055413 | 0.84 | HTR1A (0.70) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL29633081 | 0.84 | HTR1A (0.70) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL2535214 | 0.84 | TRPM8 (0.78) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Mebufotenin SCHEMBL29351950 | 0.83 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Mebufotenin SCHEMBL31098269 | 0.83 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637593-A | MIGRAINE; HYPOTENSIVE AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-10 | — | — | US | disclosed |
| EP-0674619-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014770-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |