Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | SPOP | O43791 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8673740 | 1.00 | MAPK1 (0.43) | MAPK1CA5ASPOPTDP1MAPT | |
| SCHEMBL8868325 | 0.94 | SPOP (0.42) | MAPK1CA5ASPOPTDP1MAPT | |
| SCHEMBL8670220 | 0.94 | SPOP (0.42) | MAPK1CA5ASPOPTDP1MAPT | |
| SCHEMBL8671192 | 0.90 | MAPK1 (0.54) | MAPK1CA5ASPOPTDP1MAPT | |
| SCHEMBL8674886 | 0.90 | MAPK1 (0.54) | MAPK1CA5ASPOPTDP1MAPT | |
| SCHEMBL8669790 | 0.85 | MAPK1 (0.39) | MAPK1CA5ASPOPTDP1MAPT | |
| SCHEMBL8869057 | 0.85 | MAPK1 (0.39) | MAPK1CA5ASPOPTDP1MAPT | |
| SCHEMBL8674906 | 0.84 | TDP1 (0.60) | MAPK1SPOPTDP1MAPTPOLB | |
| SCHEMBL8876120 | 0.84 | TDP1 (0.60) | MAPK1SPOPTDP1MAPTPOLB | |
| SCHEMBL8869065 | 0.84 | MAPK1 (0.54) | MAPK1CA5ASPOPTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604218-A | EXHIBITS ACTIVITY AGAINST METHICILLIN RESISTANT BACTERIA | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-02-18 | — | — | US | disclosed |
| US-5593986-A | Cephalosporin antibiotics | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-01-14 | — | — | US | disclosed |