SCHEMBL8870844

SCHEMBL8870844

Cn1c(=O)oc2cc(CCCCN3CCC(c4ccccc4)CC3)ccc21

nearest known ligand 0.66

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.66
HTR1A P08908 1/20 0.61
TP53 P04637 2/20 0.58
MEN1 O00255 1/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
TSHR P16473 1/20 0.58
CYP2C19 P33261 1/20 0.58
KMT2A Q03164 1/20 0.58
ASAH1 Q13510 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.48
DRD2 P14416 1/20 0.48
DRD4 P21917 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8870202 0.93 SIGMAR1 (0.64) SIGMAR1HTR1ATP53ASAH1L3MBTL1
SCHEMBL8871026 0.87 SIGMAR1 (0.66) SIGMAR1HTR1ATP53L3MBTL1
SCHEMBL8948004 0.84 HTR1A (0.58) SIGMAR1HTR1ACYP1A2CYP3A4CYP2D6
SCHEMBL10393710 0.80 HTR1A (0.67) SIGMAR1HTR1AMEN1KMT2ADRD2
SCHEMBL9464205 0.80 HTR1A (0.61) SIGMAR1HTR1ATP53TSHR
SCHEMBL8109444 0.79 SIGMAR1 (0.58) SIGMAR1TP53MEN1CYP1A2CYP3A4
SCHEMBL8117008 0.79 SIGMAR1 (1.00) SIGMAR1HTR1ATP53MEN1CYP1A2
SCHEMBL8870163 0.79 SIGMAR1 (0.64) SIGMAR1HTR1ATP53L3MBTL1
SCHEMBL9464567 0.79 HTR1A (0.62) SIGMAR1HTR1ATP53TSHRL3MBTL1
SCHEMBL9464220 0.79 HTR1A (0.60) SIGMAR1HTR1ATP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5688811-A PSYCHOLOGICAL DISORDERS; NERVOUS SYSTEM DISORDERS ADIR ET COMPAGNIE (FR) 1997-11-18 US disclosed
US-5534511-A AFFINITY FOR SIGMA RECEPTORS, ANTIINFLAMMATORY, TREATMENT OF ARTHRITIS ADIR ET COMPAGNIE (FR) 1996-07-09 US disclosed