Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TACR1 | P25103 | 9/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871739 | 0.84 | TACR1 (0.45) | MAPTTACR1KCNH2CYP2D6HTR1A | |
| SCHEMBL8872302 | 0.78 | L3MBTL1 (0.58) | MAPTMEN1KMT2ACYP2D6POLB | |
| SCHEMBL15118586 | 0.74 | KCNH2 (0.50) | TACR1KCNH2CYP2D6HTR1AHTR2A | |
| SCHEMBL13351975 | 0.72 | NPC1 (0.52) | POLBALDH1A1LMNA | |
| SCHEMBL3205585 | 0.71 | HCRTR1 (0.46) | TACR1KCNH2CYP2D6HTR1AHTR2A | |
| SCHEMBL5768808 | 0.71 | TACR1 (0.50) | TACR1KCNH2CYP2D6HTR1AHTR2A | |
| SCHEMBL22220774 | 0.69 | HCRTR1 (0.49) | TACR1KCNH2CYP2D6HTR1AHTR2A | |
| SCHEMBL5598110 | 0.68 | PPARG (0.50) | TACR1KCNH2CYP2D6ALDH1A1HTT | |
| SCHEMBL15173398 | 0.68 | ADRA1A (0.51) | TACR1KCNH2CYP2D6HTR1AHTR2A | |
| SCHEMBL3202940 | 0.68 | TACR1 (0.46) | TACR1KCNH2CYP2D6HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663349-A | Preparation of substituted piperidenes | PFIZER INC (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0619806-B1 | PREPARATION OF SUBSTITUTED PIPERIDINES | PFIZER (US) | 1996-01-03 | — | — | EP | disclosed |
| US-5364943-A | Preparation of substituted piperidines | PFIZER INC. (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0619806-A1 | PREPARATION OF SUBSTITUTED PIPERIDINES. | PFIZER (US) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993011110-A1 | PREPARATION OF SUBSTITUTED PIPERIDINES | PFIZER INC. (US) | 1993-06-10 | — | — | WO | disclosed |