Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.77 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871051 | 0.94 | HTR1A (0.71) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871283 | 0.91 | HTR1A (0.69) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871477 | 0.90 | HTR1A (0.63) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8553783 | 0.88 | HTR1A (0.81) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8870806 | 0.84 | HTR1A (0.59) | HTR1ACYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL8558887 | 0.83 | HTR1A (0.73) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL10575993 | 0.83 | HTR1A (0.76) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8554084 | 0.83 | HTR1A (0.78) | HTR1ADRD2DRD3 | |
| SCHEMBL8871095 | 0.82 | HTR1A (0.61) | HTR1ACYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL8871022 | 0.81 | HTR1A (0.58) | HTR1ACYP1A2CYP3A4MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |