Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870806 | 0.84 | HTR1A (0.59) | HTR1ADRD2DRD3TDP1CYP1A2 | |
| SCHEMBL8556346 | 0.84 | SIGMAR1 (0.74) | HTR1ADRD2DRD3TDP1CYP1A2 | |
| SCHEMBL8871306 | 0.82 | HTR1A (0.77) | HTR1ADRD2DRD3TDP1CYP1A2 | |
| SCHEMBL8871022 | 0.82 | HTR1A (0.58) | HTR1ADRD2DRD3TDP1CYP1A2 | |
| SCHEMBL10574063 | 0.80 | SIGMAR1 (0.60) | HTR1ADRD2DRD3TDP1CYP1A2 | |
| SCHEMBL8871051 | 0.78 | HTR1A (0.71) | HTR1ADRD2DRD3TDP1CYP1A2 | |
| SCHEMBL8554084 | 0.77 | HTR1A (0.78) | HTR1ADRD2DRD3HTR2A | |
| Roxindole SCHEMBL49673 | 0.76 | TDP1 (1.00) | HTR1ADRD2DRD3TDP1CYP1A2 | |
| SCHEMBL10355142 | 0.76 | TDP1 (0.85) | HTR1ADRD2DRD3TDP1CYP1A2 | |
| Roxindole SCHEMBL5605611 | 0.76 | TDP1 (1.00) | HTR1ADRD2DRD3TDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |