Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.40 |
| ▸ | MMP8 | P22894 | 7/20 | 0.40 |
| ▸ | MMP9 | P14780 | 4/20 | 0.40 |
| ▸ | FCER2 | P06734 | 6/20 | 0.40 |
| ▸ | MMP1 | P03956 | 11/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 8/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 4/20 | 0.35 |
| ▸ | MMP20 | O60882 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP10 | P09238 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MMP15 | P51511 | 1/20 | 0.35 |
| ▸ | MMP16 | P51512 | 1/20 | 0.35 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.35 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871312 | 1.00 | MMP2 (0.40) | MMP2MMP8MMP9FCER2MMP1 | |
| SCHEMBL8872299 | 0.75 | MMP1 (0.51) | MMP2MMP8MMP9FCER2MMP1 | |
| SCHEMBL8872304 | 0.75 | MMP1 (0.51) | MMP2MMP8MMP9FCER2MMP1 | |
| SCHEMBL8871692 | 0.74 | MMP2 (0.58) | MMP2MMP8MMP9FCER2MMP1 | |
| SCHEMBL8871696 | 0.74 | MMP2 (0.58) | MMP2MMP8MMP9FCER2MMP1 | |
| SCHEMBL8872951 | 0.74 | MMP2 (0.57) | MMP2MMP8MMP9FCER2MMP1 | |
| SCHEMBL8872944 | 0.74 | MMP2 (0.57) | MMP2MMP8MMP9FCER2MMP1 | |
| SCHEMBL7377058 | 0.73 | HDAC7 (0.46) | MMP2MMP8MMP9FCER2MMP1 | |
| SCHEMBL7841776 | 0.71 | GRIK1 (0.34) | — | |
| SCHEMBL25381978 | 0.67 | MMP8 (0.50) | MMP8FCER2ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703092-A | TREATING ARTHRITIS, OTHER INFLAMMATORY DISEASES MEDIATED BY MATRIX METALLOPROTEINASE AND/OR TUMOR NECROSIS FACTOR | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-12-30 | — | — | US | claimed |
| US-5703092-A | TREATING ARTHRITIS, OTHER INFLAMMATORY DISEASES MEDIATED BY MATRIX METALLOPROTEINASE AND/OR TUMOR NECROSIS FACTOR | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-12-30 | — | — | US | disclosed |