Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873707 | 0.81 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1PKMKDM4E | |
| SCHEMBL9323818 | 0.80 | KMT2A (0.76) | KMT2AMEN1ATMALDH1A1PTPN1 | |
| SCHEMBL8872124 | 0.78 | KMT2A (0.65) | KMT2AMEN1ATMALDH1A1PTPN1 | |
| SCHEMBL9325767 | 0.78 | KMT2A (0.77) | KMT2AMEN1ATMALDH1A1PTPN1 | |
| SCHEMBL8873587 | 0.77 | KMT2A (0.67) | KMT2AMEN1ATMALDH1A1PTPN1 | |
| SCHEMBL9323617 | 0.76 | KMT2A (0.73) | KMT2AMEN1ATMALDH1A1PTPN1 | |
| SCHEMBL9323944 | 0.75 | KMT2A (0.72) | KMT2AMEN1ATMALDH1A1KDM4E | |
| SCHEMBL9324908 | 0.75 | KMT2A (0.72) | KMT2AMEN1ATMALDH1A1PTPN1 | |
| SCHEMBL6978730 | 0.74 | KMT2A (0.70) | KMT2AMEN1ATMALDH1A1PTPN1 | |
| SCHEMBL6978776 | 0.74 | KMT2A (0.70) | KMT2AMEN1ATMALDH1A1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681843-A | ANTIDIABETIC; ALDOSE REDUCTASE INHIBITOR WITHOUT SUBSTANTIALLY INHIBITING ALDEHYDE REDUCATASE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0718289-A1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |