Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | UBE2N | P61088 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8143584 | 0.83 | KMT2A (0.76) | KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL8871897 | 0.82 | KMT2A (0.56) | KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL8873587 | 0.82 | KMT2A (0.67) | KMT2AATMALDH1A1MEN1MAPK1 | |
| SCHEMBL8136035 | 0.74 | KMT2A (0.78) | KMT2AATMMAPT | |
| SCHEMBL8872785 | 0.74 | KMT2A (0.63) | KMT2AATMMAPTALDH1A1MEN1 | |
| SCHEMBL8144324 | 0.74 | KMT2A (0.58) | KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL8150342 | 0.73 | MAPT (0.68) | KMT2AMAPTRAB9ALMNAALDH1A1 | |
| SCHEMBL8149456 | 0.73 | KMT2A (0.56) | KMT2AMAPTRAB9ALMNAALDH1A1 | |
| SCHEMBL8144325 | 0.73 | KMT2A (0.56) | KMT2AMAPTRAB9AALDH1A1 | |
| SCHEMBL8873707 | 0.72 | ALDH1A1 (0.56) | KMT2AKDM4ELMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681843-A | ANTIDIABETIC; ALDOSE REDUCTASE INHIBITOR WITHOUT SUBSTANTIALLY INHIBITING ALDEHYDE REDUCATASE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0718289-A1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |