SCHEMBL8872154

SCHEMBL8872154

CC1c2cc(Cl)ccc2C(=O)C1(CBr)C(=O)O

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
SLC6A9 P48067 1/20 0.33
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
PPOX P50336 1/20 0.32
SHMT1 P34896 1/20 0.32
SHMT2 P34897 1/20 0.32
WDR5 P61964 1/20 0.31
ATM Q13315 1/20 0.31
FFAR1 O14842 1/20 0.31
PPARG P37231 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
AKR1B1 P15121 2/20 0.31
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
S100A4 P26447 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9589487 0.77 MEN1 (0.36) MEN1KMT2ASLC6A9ALDH1A1TP53
SCHEMBL1876338 0.77 MEN1 (0.36) MEN1KMT2ASLC6A9ALDH1A1TP53
SCHEMBL4950320 0.77 MEN1 (0.36) MEN1KMT2ASLC6A9ALDH1A1TP53
SCHEMBL28355810 0.74 MEN1 (0.34) MEN1KMT2ASLC6A9ALDH1A1TP53
SCHEMBL9587304 0.61 HTR2B (0.36) MEN1KMT2AALDH1A1PPOXS100A4
SCHEMBL14991575 0.60 MKNK2 (0.46) MEN1KMT2APPOXCA1CA2
SCHEMBL9188549 0.59 HPGD (0.42) ALDH1A1FFAR1CYP11B1CYP11B2
SCHEMBL25834345 0.59 PPOX (0.41) MEN1KMT2ASLC6A9ALDH1A1PPOX
SCHEMBL30633032 0.59 S100A4 (0.41) MEN1KMT2ATP53PPOXCA1
SCHEMBL8993316 0.59 S100A4 (0.41) MEN1KMT2ATP53PPOXCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5591729-A INSECTICIDES, PESTICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1997-01-07 US disclosed