Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | HTR7 | P34969 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876236 | 0.74 | HTR1A (0.56) | HTR1AHTR7DRD2DRD3 | |
| SCHEMBL9195680 | 0.73 | CHRM3 (0.66) | CHRM3CHRM2CHRM1HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL9359509 | 0.73 | DRD2 (0.58) | DRD2DRD4DRD3 | |
| SCHEMBL4207429 | 0.73 | HTR6 (0.59) | HTR6CHRM3CHRM2CHRM1HTR1A | |
| SCHEMBL3205572 | 0.72 | HTR6 (1.00) | HTR6HTR1ADRD2DRD3 | |
| SCHEMBL14591308 | 0.72 | CHRM3 (0.69) | CHRM3CHRM2CHRM1HTR1AHTR7 | |
| SCHEMBL6540873 | 0.71 | CHRM3 (0.67) | CHRM3CHRM2CHRM1HTR1AHTR7 | |
| SCHEMBL5361640 | 0.71 | CHRM3 (0.67) | CHRM3CHRM2CHRM1HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL6542162 | 0.71 | CHRM3 (0.67) | CHRM3CHRM2CHRM1HTR1AHTR7 | |
| SCHEMBL8891132 | 0.71 | CHRM3 (1.00) | CHRM3CHRM2CHRM1HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637624-A | ANTISEROTONIN AGENT | ELI LILLY AND COMPANY (US) | 1997-06-10 | — | — | US | disclosed |
| US-5594034-A | ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5457120-A | Antisecretory and antiserotonine agents | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0385658-B1 | Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | LILLY CO ELI (US) | 1994-12-28 | — | — | EP | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| EP-0385658-A1 | Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | ELI LILLY AND COMPANY (US) | 1990-09-05 | — | — | EP | disclosed |