Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 5/20 | 0.36 |
| ▸ | CA1 | P00915 | 5/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CA9 | Q16790 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875945 | 0.92 | MAPT (0.43) | MAPTNPSR1CA12CA1CA2 | |
| SCHEMBL8098569 | 0.90 | MAPT (0.40) | MAPTNPSR1KDM4ECA12CA1 | |
| SCHEMBL8098573 | 0.83 | MAPT (0.42) | MAPTNPSR1CA12CA1CA2 | |
| SCHEMBL8917687 | 0.81 | MAPT (0.45) | MAPTNPSR1CA12CA1CA2 | |
| SCHEMBL8875576 | 0.78 | MAPT (0.49) | MAPTNPSR1CA12CA1CA2 | |
| SCHEMBL8768350 | 0.75 | MAPT (0.44) | MAPTNPSR1CA12CA1CA2 | |
| SCHEMBL8875047 | 0.74 | SMN1; SMN2 (0.36) | MAPTKMT2ALMNASMN1; SMN2PTGS2 | |
| SCHEMBL9140513 | 0.73 | MAPT (0.50) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL8868264 | 0.73 | MAPT (0.52) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL9137896 | 0.72 | MAPT (0.55) | MAPTNPSR1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620996-A | Sulfonamidocarbonyl pyridine-2-carboxesteramides and their pyridine-N-oxide compounds and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |