Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916374 | 0.91 | ROCK2 (0.48) | MAPTBCL2L1MCL1PTGS1PTGS2 | |
| SCHEMBL8768350 | 0.89 | MAPT (0.44) | MAPTBCL2L1MCL1PTGS1PTGS2 | |
| SCHEMBL8916345 | 0.85 | EGLN1 (0.51) | MAPTBCL2L1MCL1PTGS1PTGS2 | |
| SCHEMBL8915243 | 0.83 | LMNA (0.45) | MAPTMEN1KMT2ACA12CA1 | |
| SCHEMBL8917435 | 0.82 | LMNA (0.38) | PTGS2CA1CA2CA9LMNA | |
| SCHEMBL8917593 | 0.82 | L3MBTL1 (0.43) | MAPTKMT2ANPC1RAB9ANPSR1 | |
| SCHEMBL8768266 | 0.81 | ROCK2 (0.46) | MAPTBCL2L1MCL1PTGS1PTGS2 | |
| SCHEMBL8874763 | 0.81 | MAPT (0.41) | MAPTBCL2L1MCL1PTGS1PTGS2 | |
| SCHEMBL8867801 | 0.80 | MAPT (0.52) | MAPTBCL2L1MCL1PTGS1PTGS2 | |
| SCHEMBL9140513 | 0.78 | MAPT (0.50) | MAPTBCL2L1MCL1PTGS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | disclosed |