Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874763 | 0.92 | MAPT (0.41) | MAPTTSHRROCK2ROCK1NPSR1 | |
| SCHEMBL8098573 | 0.89 | MAPT (0.42) | MAPTTSHRROCK2ROCK1NPSR1 | |
| SCHEMBL8098569 | 0.83 | MAPT (0.40) | MAPTTSHRROCK2ROCK1NPSR1 | |
| SCHEMBL8875576 | 0.80 | MAPT (0.49) | MAPTNPSR1CA1CA2CA9 | |
| SCHEMBL8916374 | 0.79 | ROCK2 (0.48) | MAPTTSHRROCK2ROCK1CA1 | |
| SCHEMBL8868264 | 0.75 | MAPT (0.52) | MAPTTSHRCA1CA2CA9 | |
| SCHEMBL9137896 | 0.74 | MAPT (0.55) | MAPTTSHRNPSR1CA1CA2 | |
| SCHEMBL9139948 | 0.74 | MAPT (0.55) | MAPTTSHRNPSR1CA1CA2 | |
| SCHEMBL9018414 | 0.73 | MAPT (0.54) | MAPTNPSR1CA1CA2CA9 | |
| SCHEMBL9018324 | 0.73 | MAPT (0.54) | MAPTNPSR1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620996-A | Sulfonamidocarbonyl pyridine-2-carboxesteramides and their pyridine-N-oxide compounds and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |