Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768266 | 0.91 | ROCK2 (0.46) | MAPTBCL2L1MCL1MEN1KMT2A | |
| SCHEMBL8917687 | 0.89 | MAPT (0.45) | MAPTBCL2L1MCL1MEN1KMT2A | |
| SCHEMBL9235404 | 0.87 | MAPT (0.46) | MAPTBCL2L1MCL1MEN1KMT2A | |
| SCHEMBL8768265 | 0.84 | LMNA (0.44) | MAPTMEN1KMT2ACA12CA1 | |
| SCHEMBL8767144 | 0.83 | LMNA (0.38) | PTGS2LMNASMN1; SMN2HTT | |
| SCHEMBL8767453 | 0.83 | LMNA (0.42) | MAPTKMT2ANPSR1NPC1RAB9A | |
| SCHEMBL8916374 | 0.81 | ROCK2 (0.48) | MAPTBCL2L1MCL1MEN1KMT2A | |
| SCHEMBL8098569 | 0.81 | MAPT (0.40) | MAPTMEN1KMT2APTGS1PTGS2 | |
| SCHEMBL8105999 | 0.79 | MAPT (0.47) | MAPTBCL2L1MCL1MEN1KMT2A | |
| SCHEMBL9195194 | 0.78 | BCL2L1 (0.50) | MAPTBCL2L1MCL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673931-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 1997-08-13 | — | — | EP | disclosed |
| EP-0673931-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |