Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29796329 | 0.81 | PLCG1 (0.68) | PLCG1KMT2AMEN1NOX1CA2 | |
| SCHEMBL5119459 | 0.81 | PLCG1 (0.68) | PLCG1KMT2AMEN1NOX1CA2 | |
| Hydrochloric Acid SCHEMBL26961260 | 0.79 | PLCG1 (0.66) | PLCG1KMT2AMEN1NOX1CA2 | |
| SCHEMBL18173741 | 0.78 | PLCG1 (0.65) | PLCG1KMT2AMEN1NOX1CA2 | |
| SCHEMBL88913 | 0.78 | PLCG1 (0.65) | PLCG1KMT2AMEN1NOX1CA2 | |
| SCHEMBL3598842 | 0.76 | PLCG1 (0.61) | PLCG1CA2CA12CA1CA9 | |
| SCHEMBL3600873 | 0.76 | PLCG1 (0.61) | PLCG1KMT2AMEN1CA2CA12 | |
| SCHEMBL10420771 | 0.76 | PLCG1 (0.61) | PLCG1CA2CA12CA1CA9 | |
| SCHEMBL10422383 | 0.74 | PLCG1 (0.58) | PLCG1KMT2AMEN1NOX1CA2 | |
| SCHEMBL10422382 | 0.74 | PLCG1 (0.58) | PLCG1KMT2AMEN1NOX1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9977024-B2 | Targeted covalent probes and inhibitors of proteins containing redox-sensitive cysteines | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| US-9977024-B2 | Targeted covalent probes and inhibitors of proteins containing redox-sensitive cysteines | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| WO-2018079628-A1 | PYRROLE DERIVATIVE WITH FUSED RING AND PHARMACEUTICAL USE THEREOF | 大日本住友製薬株式会社 | 2018-05-03 | — | — | WO | disclosed |
| US-9758480-B2 | 1-(cycloalkyl-carbonyl)proline derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-9758480-B2 | 1-(cycloalkyl-carbonyl)proline derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-20160318933-A1 | FUSED PYRAZOLE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2016-11-03 | — | — | US | disclosed |
| US-20160318933-A1 | FUSED PYRAZOLE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2016-11-03 | — | — | US | disclosed |
| WO-2016171181-A1 | 2-SUBSTITUTED FUSED PYRAZOLE DERIVATIVES | 大日本住友製薬株式会社 | 2016-10-27 | — | — | WO | disclosed |
| US-20160195532-A1 | Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines | THE SCRIPPS RESEARCH INSTITUTE | 2016-07-07 | — | — | US | disclosed |
| US-20160195532-A1 | Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines | THE SCRIPPS RESEARCH INSTITUTE | 2016-07-07 | — | — | US | disclosed |
| US-6127360-A | ANTIHISTAMINES, ANTILEUKOTRIENES, ANTIINFLAMMATORY AGENTS, ANTIASTHMATIC AGENTS | KOWA CO., LTD. (JP) | 2000-10-03 | — | — | US | disclosed |
| EP-0846112-A1 | BICYCLIC HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5202341-A | HYDROXYSTYRENE COMPOUNDS HAVING TYROSINE KINASE INHIBITING ACTIVITY | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1993-04-13 | — | — | US | disclosed |
| EP-0304493-B1 | HYDROXYSTYRENE DERIVATIVES | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1992-09-02 | — | — | EP | disclosed |
| US-5089516-A | Antiallergens, bactericides | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1992-02-18 | — | — | US | disclosed |
| US-5057538-A | Antiallergen, 5-lipoxygenase inhibitor, bactericide, ultraviolet absorber, and reverse transcriptase inhibitor | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-10-15 | — | — | US | disclosed |
| US-4971996-A | Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-11-20 | — | — | US | disclosed |
| US-4960870-A | DYEING WOOL, POLYAMIDES; FIBER REACTIVE DYES | CIBA-GEIGY CORPORATION (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0304493-A1 | HYDROXYSTYRENE DERIVATIVES | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-03-01 | — | — | EP | disclosed |
| EP-0055917-B1 | NEW BENZOTHIAZINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318933-A1 | FUSED PYRAZOLE DERIVATIVE | DRD4, DRD2, DRD3 | PLCG1 3025/4885KMT2A 1448/4885MEN1 4717/4885 |
| US-20160195532-A1 | Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines | PTMS, RSU1, QSOX1 | PLCG1 1959/4885KMT2A 3014/4885MEN1 4819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.