Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.47 |
| ▸ | HTR2C known ✓ | P28335 | 5/20 | 0.47 |
| ▸ | NQO2 | P16083 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8875270 | 1.00 | HTR2A (0.47) | HTR2AHTR2CNQO2MTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8873545 | 0.91 | HTR2C (0.57) | HTR2AHTR2CNQO2MTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8873552 | 0.91 | HTR2C (0.57) | HTR2AHTR2CNQO2MTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8874078 | 0.91 | HTR2A (0.47) | HTR2AHTR2CALDH1A1NPC1LMNA | |
| Fumaric Acid SCHEMBL8874089 | 0.91 | HTR2A (0.47) | HTR2AHTR2CALDH1A1NPC1LMNA | |
| SCHEMBL8875204 | 0.90 | HTR2C (0.55) | HTR2AHTR2CSIGMAR1TYMSALDH1A1 | |
| Fumaric Acid SCHEMBL8872857 | 0.85 | HTR2C (0.67) | HTR2AHTR2CNQO2MTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8872866 | 0.85 | HTR2C (0.67) | HTR2AHTR2CNQO2MTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8874825 | 0.85 | HTR2C (0.67) | HTR2AHTR2CNQO2MTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL8874818 | 0.85 | HTR2C (0.67) | HTR2AHTR2CNQO2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |