Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8878392 | 0.99 | LMNA (0.62) | LMNAALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL8875644 | 0.86 | LMNA (0.65) | LMNAALDH1A1MAPTKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL8876509 | 0.86 | LMNA (0.64) | LMNAALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL8875658 | 0.85 | HTR1A (0.68) | LMNAALDH1A1KDM4EHTR1AADRA1D | |
| SCHEMBL8876505 | 0.84 | HTR1A (0.71) | LMNAALDH1A1HTR1AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL8875702 | 0.84 | HTR1A (0.66) | LMNAALDH1A1KDM4EHTR1AADRA1D | |
| SCHEMBL8876415 | 0.84 | HTR1A (0.70) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8875577 | 0.84 | HTR1A (0.70) | LMNAALDH1A1HTR1AADRA1DADRA1A | |
| SCHEMBL8876618 | 0.83 | HTR1A (0.69) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8875342 | 0.83 | HTR1A (0.69) | LMNAALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040434-C | Heterobicyclic compounds | RECORDATI CHEM PHARM (CH) | 1998-10-28 | — | — | CN | claimed |
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | claimed |