Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | HTR1A | P08908 | 4/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8876509 | 0.99 | LMNA (0.64) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| SCHEMBL8875106 | 0.92 | ALDH1A1 (0.55) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL8875096 | 0.92 | ALDH1A1 (0.54) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| SCHEMBL8877659 | 0.92 | HTR1A (0.65) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| SCHEMBL8875442 | 0.91 | HTR1A (0.69) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL8877171 | 0.91 | HTR1A (0.65) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| SCHEMBL8877620 | 0.89 | SMN1; SMN2 (0.51) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL8876350 | 0.89 | HTR1A (0.67) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL8876083 | 0.89 | SMN1; SMN2 (0.51) | LMNAALDH1A1HTR1AADRA1AADRA1D | |
| SCHEMBL8876571 | 0.87 | LMNA (0.60) | LMNAALDH1A1HTR1AADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040434-C | Heterobicyclic compounds | RECORDATI CHEM PHARM (CH) | 1998-10-28 | — | — | CN | claimed |
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | claimed |
| WO-1993017007-A1 | HETEROBICYCLIC COMPOUNDS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 1993-09-02 | — | — | WO | claimed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | claimed |