Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875540 | 0.93 | HTR1A (0.59) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL7050353 | 0.90 | HTR1A (0.61) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| Hydrochloric Acid SCHEMBL8877043 | 0.89 | HTR1A (0.60) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL7052213 | 0.88 | HTR1A (0.58) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL11034050 | 0.87 | HTR1A (0.57) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL10988543 | 0.85 | LMNA (0.57) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL10984054 | 0.85 | HTR1A (0.75) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL10991960 | 0.83 | HTR1A (0.72) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL9567480 | 0.83 | HTR1A (0.57) | HTR1AADRA1AADRA1DADRA1BLMNA | |
| SCHEMBL10988357 | 0.83 | HTR1A (0.70) | HTR1AADRA1AADRA1DADRA1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658587-A | TRANSDERMAL PATCH | FLORA INC. (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1997014419-A1 | TRANSDERMAL DELIVERY OF ALPHA ADRENOCEPTOR BLOCKING AGENTS | FLORA INC. (US) | 1997-04-24 | — | — | WO | disclosed |
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | disclosed |
| EP-0756482-A1 | TRANSDERMAL DELIVERY OF ALPHA ADRENOCEPTOR BLOCKING AGENTS | FLORA INC. (US) | 1997-02-05 | — | — | EP | disclosed |
| US-5503843-A | PATCH HAVING EITHER A LIQUID RESERVOIR OR MONOLITHIC MATRIX CONTAINING A PERMEATION ENHANCER AND 2-PHENYL-3-METHYL-8-(1-(4-(METHOXYPHENYL)PIPERAZIN-1-YL)PROPYLAMINO-4 -CARBONYL-4H-CHROMEN-4-ONE; BENIGN PROSTRATE HYPERPLASIA | FLORA INC. (US) | 1996-04-02 | — | — | US | disclosed |
| US-5474994-A | Treating hypertension, urethral and lower urinary tract contractions | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-12-12 | — | — | US | disclosed |
| WO-1995028932-A1 | TRANSDERMAL DELIVERY OF ALPHA ADRENOCEPTOR BLOCKING AGENTS | FLORA INC. (US) | 1995-11-02 | — | — | WO | disclosed |
| US-5453518-A | Antispasmodic agents, treatment of urinary incontinence | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-09-26 | — | — | US | disclosed |
| EP-0566288-B1 | Flavone derivatives | RECORDATI CHEM PHARM (CH) | 1995-08-02 | — | — | EP | disclosed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | disclosed |
| EP-0566288-A1 | Flavone derivatives | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993017007-A1 | HETEROBICYCLIC COMPOUNDS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 1993-09-02 | — | — | WO | disclosed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | disclosed |