Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917687 | 0.91 | MAPT (0.45) | ROCK2ROCK1MAPTTSHRCA1 | |
| SCHEMBL8916345 | 0.88 | EGLN1 (0.51) | MAPTCA1CA2CA9BCL2L1 | |
| SCHEMBL8768266 | 0.88 | ROCK2 (0.46) | ROCK2ROCK1MAPTTSHRALDH1A1 | |
| SCHEMBL8915470 | 0.83 | LMNA (0.49) | MAPTTSHRALDH1A1CA1CA2 | |
| SCHEMBL8867801 | 0.83 | MAPT (0.52) | MAPTTSHRCA1CA2CA9 | |
| SCHEMBL8915935 | 0.82 | PTGS2 (0.51) | MCL1PTGS1PTGS2 | |
| SCHEMBL8868966 | 0.82 | TSHR (0.58) | MAPTTSHRALDH1A1USP2CA1 | |
| SCHEMBL8916746 | 0.81 | EGLN1 (0.42) | CA1CA2CA9PTGS1PTGS2 | |
| SCHEMBL8768350 | 0.81 | MAPT (0.44) | ROCK2ROCK1MAPTTSHRCA1 | |
| SCHEMBL8916898 | 0.81 | L3MBTL1 (0.52) | MAPTTSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7278109-A | — | — | None | — | — | JP | disclosed |
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | disclosed |
| JP-H07278109-A | SULFONAMIDOCARBONYLPYRIDINE-2-CARBOXAMIDE, PYRIDINE-N-OXIDE THEREOF, PREPARATION THEREOF AND USE THEREOF AS DRUG | HOECHST AG | 1995-10-24 | — | — | JP | disclosed |