Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878677 | 0.94 | CCR2 (0.54) | CCR2MAPTDRD3TP53MEN1 | |
| SCHEMBL8877651 | 0.94 | CCR2 (0.50) | CCR2MAPTDRD3MEN1KMT2A | |
| SCHEMBL8878411 | 0.90 | CCR2 (0.53) | CCR2DRD3KMT2ADRD1DRD4 | |
| SCHEMBL9033599 | 0.89 | CCR2 (0.47) | CCR2MAPTDRD3TP53MEN1 | |
| SCHEMBL8876587 | 0.89 | CCR2 (0.51) | CCR2TP53HTR1AHTR2ADRD2 | |
| SCHEMBL8876997 | 0.89 | ADRA1D (0.50) | CCR2HTR1AHTR2ADRD2HTR7 | |
| SCHEMBL8879724 | 0.88 | CCR2 (0.56) | CCR2HTR1AHTR2ADRD2HTR7 | |
| SCHEMBL8876701 | 0.88 | CCR2 (0.56) | CCR2DRD3TP53DRD4HTR2A | |
| SCHEMBL8876932 | 0.88 | ADRA1D (0.54) | CCR2DRD4HTR2ADRD2HTR7 | |
| SCHEMBL8878564 | 0.88 | CCR2 (0.47) | CCR2MAPTDRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |