Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 12/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | FAP | Q12884 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877476 | 0.94 | CCR2 (0.53) | CCR2DRD4DRD3DRD1DRD2 | |
| SCHEMBL8878564 | 0.91 | CCR2 (0.47) | CCR2DRD3KDM4EALDH1A1GAA | |
| SCHEMBL8876575 | 0.90 | CCR2 (0.50) | CCR2DRD4DRD3DRD1KDM4E | |
| SCHEMBL9035293 | 0.88 | CCR2 (0.49) | CCR2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL8876701 | 0.88 | CCR2 (0.56) | CCR2DRD4DRD3DRD2HTR2A | |
| SCHEMBL8876932 | 0.88 | ADRA1D (0.54) | CCR2DRD4DRD2HTR2A | |
| SCHEMBL8877646 | 0.87 | CCR2 (0.53) | CCR2DRD4DRD3KDM4EALDH1A1 | |
| SCHEMBL8878843 | 0.86 | CCR2 (0.54) | CCR2DRD4DRD3DRD2 | |
| SCHEMBL8878100 | 0.86 | CCR2 (0.48) | CCR2DRD4DRD3DRD1DRD2 | |
| SCHEMBL8878677 | 0.86 | CCR2 (0.54) | CCR2DRD3KMT2ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |