Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.42 |
| ▸ | TYMS | P04818 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | FABP6 | P51161 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595901 | 0.89 | SRD5A1 (0.42) | PARP1PARP10SRD5A1MAPK14 | |
| SCHEMBL8877618 | 0.75 | SRD5A1 (0.42) | PARP1PARP10SRD5A1TYMS | |
| SCHEMBL5518824 | 0.75 | PARP1 (0.58) | PARP1PARP10SRD5A1TYMSMAPK14 | |
| SCHEMBL9591164 | 0.72 | SLC11A2 (0.41) | — | |
| SCHEMBL9591939 | 0.72 | PNMT (0.39) | — | |
| SCHEMBL8251126 | 0.69 | MAPK14 (0.55) | PARP1PARP10SRD5A1MAPK14TDP1 | |
| SCHEMBL4157894 | 0.67 | TDP1 (0.64) | PARP1PARP10SRD5A1MAPK14TDP1 | |
| SCHEMBL4184575 | 0.66 | — | — | |
| SCHEMBL29443089 | 0.66 | PBRM1 (0.59) | PARP1PARP10SRD5A1TYMSACHE | |
| SCHEMBL1150109 | 0.66 | PBRM1 (0.59) | PARP1PARP10SRD5A1TYMSACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665726-A | ANTIALLERGIC, ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1997-09-09 | — | — | US | disclosed |
| US-5438062-A | Antiallergens, antiinflammatory agents | SCHERING CORPORATION (US) | 1995-08-01 | — | — | US | disclosed |
| EP-0270818-B1 | Benzo(5,6)cycloheptapyridines, compositions and method of use | SCHERING CORP (US) | 1994-12-28 | — | — | EP | disclosed |
| US-5089496-A | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies | SCHERING CORPORATION (US) | 1992-02-18 | — | — | US | disclosed |
| US-4826853-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0270818-A1 | Benzo(5,6)cycloheptapyridines, compositions and method of use | SCHERING CORPORATION (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4659716-A | Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines | SCHERING CORPORATION (US) | 1987-04-21 | — | — | US | disclosed |