Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 3/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | VHL | P40337 | 1/20 | 0.34 |
| ▸ | ELOC | Q15369 | 1/20 | 0.34 |
| ▸ | ELOB | Q15370 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595901 | 0.83 | SRD5A1 (0.42) | SRD5A1PARP10PARP1CYP11B1CYP11B2 | |
| SCHEMBL9591939 | 0.80 | PNMT (0.39) | — | |
| SCHEMBL9591164 | 0.80 | SLC11A2 (0.41) | CYP11B1CYP11B2CYP19A1DRD2HTR2A | |
| SCHEMBL9127133 | 0.76 | CXCL12 (0.38) | METAP1PARP10F7PARP1F3 | |
| SCHEMBL8876795 | 0.75 | PARP1 (0.47) | SRD5A1TYMSPARP10PARP1 | |
| SCHEMBL2601324 | 0.75 | METAP1 (0.60) | SRD5A1METAP1TYMSSRD5A2HTT | |
| SCHEMBL10431015 | 0.71 | FNTA (0.53) | HRH1 | |
| SCHEMBL6054738 | 0.70 | SLC6A15 (0.61) | MEN1LMNACHRM2ABCB1CHRM3 | |
| SCHEMBL2312578 | 0.67 | AKR1B1 (0.58) | SRD5A1METAP1SRD5A2HTTCYP19A1 | |
| SCHEMBL4135475 | 0.67 | CES1 (0.61) | SRD5A1METAP1SRD5A2HTTS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665726-A | ANTIALLERGIC, ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0685476-A1 | Benzo(5,6)cycloheptapyridines, compositions and methods of use | SCHERING CORPORATION (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5438062-A | Antiallergens, antiinflammatory agents | SCHERING CORPORATION (US) | 1995-08-01 | — | — | US | disclosed |
| EP-0270818-B1 | Benzo(5,6)cycloheptapyridines, compositions and method of use | SCHERING CORP (US) | 1994-12-28 | — | — | EP | disclosed |
| US-5231101-A | Antihistamines | SS PHARMACEUTICAL CO., LTD. (JP) | 1993-07-27 | — | — | US | disclosed |
| EP-0288640-B1 | 6,11-Dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta-[1,2-b]pyridines and compositions and methods of use | SCHERING CORPORATION (US) | 1992-09-09 | — | — | EP | disclosed |
| EP-0495484-A1 | Novel benzo [5,6] cyclohepta [1,2-b] pyridine derivatives and antiallergic agents comprising same | SS PHARMACEUTICAL CO., LTD. (JP) | 1992-07-22 | — | — | EP | disclosed |
| US-5089496-A | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies | SCHERING CORPORATION (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0330673-A1 | BENZO 5,6]CYCLOHEPTAPYRIDINES, COMPOSITIONS AND METHODS OF USE | SCHERING CORPORATION (US) | 1989-09-06 | — | — | EP | disclosed |
| US-4804666-A | ANTIHISTAMINES | SCHERING CORPORATION (US) | 1989-02-14 | — | — | US | disclosed |
| WO-1988008423-A1 | 6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO[5,6]CYCLOHEPTA[1,2-b]PYRIDINES AND COMPOSITIONS AND METHODS OF USE | SCHERING CORPORATION (US) | 1988-11-03 | — | — | WO | disclosed |
| EP-0270818-A1 | Benzo(5,6)cycloheptapyridines, compositions and method of use | SCHERING CORPORATION (US) | 1988-06-15 | — | — | EP | disclosed |
| WO-1988003138-A1 | BENZO[5,6]CYCLOHEPTAPYRIDINES, COMPOSITIONS AND METHODS OF USE | SCHERING CORPORATION (US) | 1988-05-05 | — | — | WO | disclosed |