Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27708395 | 0.82 | TP53 (0.35) | TSHRHSD17B10 | |
| SCHEMBL8876092 | 0.79 | ALDH1A1 (0.40) | — | |
| SCHEMBL15460034 | 0.78 | ALDH1A1 (0.37) | TSHR | |
| SCHEMBL5645134 | 0.74 | ALDH1A1 (0.33) | MAPTHSD17B10 | |
| SCHEMBL1963806 | 0.72 | — | — | |
| SCHEMBL13242767 | 0.72 | — | — | |
| SCHEMBL6124890 | 0.70 | — | — | |
| SCHEMBL4570512 | 0.70 | CYP1A2 (0.45) | TSHRMAPK1KMT2A | |
| SCHEMBL14671534 | 0.69 | — | — | |
| SCHEMBL642970 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639780-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA, INC. (CA) | 1997-06-17 | — | — | US | disclosed |
| US-5604253-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS | MERCK FROSST CANADA, INC. (CA) | 1997-02-18 | — | — | US | disclosed |
| WO-1996037467-A1 | N-BENZYLINDOL-3-YL BUTANOIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1996-11-28 | — | — | WO | disclosed |