Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 8/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 4/20 | 0.47 |
| ▸ | HTR1B | P28222 | 3/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877686 | 0.91 | CCR2 (0.56) | CCR2DRD2DRD3 | |
| SCHEMBL9035452 | 0.90 | CCR2 (0.54) | CCR2DRD2HTR2AKCNH2DRD3 | |
| SCHEMBL8878623 | 0.88 | CCR2 (0.54) | CCR2DRD2DRD3 | |
| SCHEMBL8878754 | 0.88 | DRD2 (0.51) | CCR2DRD2SLC6A4HTR2AHTR7 | |
| SCHEMBL8877646 | 0.88 | CCR2 (0.53) | CCR2DRD2DRD3 | |
| SCHEMBL8878088 | 0.86 | CCR2 (0.56) | CCR2DRD2HTR2AHTR7DRD3 | |
| SCHEMBL8876714 | 0.86 | CCR2 (0.50) | CCR2DRD2HTR2ADRD3 | |
| SCHEMBL8876932 | 0.86 | ADRA1D (0.54) | ADRA1DADRA1BCCR2DRD2SLC6A4 | |
| SCHEMBL8879246 | 0.84 | CCR2 (0.54) | CCR2DRD2KCNH2DRD3 | |
| SCHEMBL8878342 | 0.84 | CCR2 (0.54) | CCR2DRD2SLC6A4HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | claimed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | claimed |
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |