Isoguanine

Isoguanine

SCHEMBL887740

Nc1nc(O)nc2[nH]cnc12

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.36
GDA Q9Y2T3 2/20 0.34
PDPK1 O15530 1/20 0.33
LMNA P02545 3/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
CSNK2A2 P19784 1/20 0.32
RAB9A P51151 1/20 0.32
CSNK2B P67870 1/20 0.32
CSNK2A1 P68400 1/20 0.32
DYRK1A Q13627 1/20 0.32
CSNK2A3 Q8NEV1 1/20 0.32
POLB P06746 1/20 0.32
XDH P47989 2/20 0.31
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TP53 P04637 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
HPGD P15428 1/20 0.31
PTGS1 P23219 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8850 0.80 GDA (0.33) PARP1GDAPDPK1LMNAXDH
SCHEMBL11977311 0.80 GDA (0.33) PARP1GDAPDPK1LMNAXDH
Xanthine SCHEMBL9443796 0.79 MEN1 (0.34) PARP1LMNAMEN1KMT2ACSNK2A2
Xanthine SCHEMBL918381 0.79 MEN1 (0.34) PARP1LMNAMEN1KMT2ACSNK2A2
2,6-Diaminopurine SCHEMBL29444619 0.79 GDA (0.48) GDAPDPK1LMNAXDHUSP2
2,6-Diaminopurine SCHEMBL24052 0.79 GDA (0.48) GDAPDPK1LMNAXDHUSP2
2,6-Diaminopurine SCHEMBL8757968 0.78 GDA (0.47) GDAPDPK1LMNAXDHUSP2
2,6-Diaminopurine SCHEMBL6423146 0.78 GDA (0.47) GDAPDPK1LMNAXDHUSP2
SCHEMBL13477906 0.77 GDA (0.32) GDAPDPK1
SCHEMBL6545701 0.76 GDA (0.34) PARP1GDAPDPK1LMNAXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 416 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260098287-A1 METHOD AND KIT FOR REGENERATING REUSABLE INITIATORS FOR NUCLEIC ACID SYNTHESIS CHENG-YAO CHEN (TW) 2026-04-09 US claimed
EP-3922266-B1 TOLL-LIKE RECEPTOR 7 OR 8 AGONIST-CHOLESTEROL COMPLEX, AND USE OF SAME PROGENEER INC (KR) 2026-04-08 EP claimed
CN-113960312-B Serum metabolism marker for diagnosing benign and malignant lung nodules and application thereof 上海市第一人民医院 2025-03-04 CN claimed
CN-118150834-A Application of marker in preparation of product for predicting IgG antibody endurance 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 2024-06-07 CN claimed
CN-117877567-A Metabolic marker for clinical early diagnosis of smoke disease and application thereof 河南省人民医院 2024-04-12 CN claimed
CN-117321218-A Regeneration method and kit of reusable initiators for nucleic acid synthesis 陈呈尧 2023-12-29 CN claimed
US-20230410977-A1 METHODS AND MATERIALS FOR ASSESSING RADIATION EXPOSURE NUTECH VENTURES 2023-12-21 US claimed
US-20230390406-A1 Star Polymer Drug Conjugates BARINTHUS BIOTHERAPEUTICS NORTH AMERICA, INC. 2023-12-07 US claimed
US-20230348903-A1 OLIGONUCLEOTIDES Hudson Institute of Medical Research (AU) 2023-11-02 US claimed
EP-4263852-A1 METHOD AND KIT FOR REGENERATING REUSABLE INITIATORS FOR NUCLEIC ACID SYNTHESIS Chen, Cheng-Yao (TW) 2023-10-25 EP claimed
EP-1455760-B1 ULTRAPURE ORAL FLUDARA FORMULATION WITH A FAST RELEASING ACTIVE SUBSTANCE SCHERING AG (DE) 2005-09-07 EP claimed
CN-1617713-A Ultrapure oral fludara formulation with a fast releasing active substance SCHERING AG (DE) 2005-05-18 CN claimed
EP-1455760-A1 ULTRAPURE ORAL FLUDARA FORMULATION WITH A FAST RELEASING ACTIVE SUBSTANCE SCHERING AKTIENGESELLSCHAFT (DE) 2004-09-15 EP claimed
EP-1430145-A2 METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) 2004-06-23 EP claimed
US-20040096863-A1 Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a dna repair enzyme and a cancer YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2004-05-20 US claimed
US-20030176391-A1 Oral fludara of high-purity formulation with quick release of active ingredient SCHERING AG (DE) 2003-09-18 US claimed
WO-2003053418-A1 ULTRAPURE ORAL FLUDARA FORMULATION WITH A FAST RELEASING ACTIVE SUBSTANCE SCHERING AKTIENGESELLSCHAFT (DE) 2003-07-03 WO claimed
US-20030003454-A1 Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a DNA repair enzyme and a cancer YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE 2003-01-02 US claimed
WO-2002076280-A2 METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2002-10-03 WO claimed
US-5352786-A Di(2-propyl)esters of 1-fluoro-2-phosphonomethoxy-3-P-to-luenesulfonyloxypropanes, their producing and utilization INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1994-10-04 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030176391-A1 Oral fludara of high-purity formulation with quick release of active ingredient CYP2C19, FCGR2A, CYP2C9 PARP1 4196/4885GDA 771/4885PDPK1 4628/4885
US-20260098287-A1 METHOD AND KIT FOR REGENERATING REUSABLE INITIATORS FOR NUCLEIC ACID SYNTHESIS DNMT3L, ADAR, UNG PARP1 204/4885GDA 113/4885PDPK1 3057/4885
US-20230390406-A1 Star Polymer Drug Conjugates CCND3, CCND2, DRD3 PARP1 380/4885GDA 3610/4885PDPK1 4103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.