Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.44 |
| ▸ | TOP1 | P11387 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878315 | 0.84 | PRKAA2 (0.43) | HMGCRTOP1RXRAPRKAA2ADORA2A | |
| SCHEMBL8880672 | 0.80 | MAPT (0.47) | TOP1PRKAA2ADORA2AADORA1MAPT | |
| SCHEMBL8877091 | 0.79 | PRKAA2 (0.60) | HMGCRTOP1PRKAA2ADORA2AADORA1 | |
| SCHEMBL8879664 | 0.79 | HMGCR (0.54) | HMGCRTOP1ADORA2AADORA1MAPT | |
| SCHEMBL8878341 | 0.75 | HMGCR (0.57) | HMGCRTOP1ADORA2AADORA1SQOR | |
| SCHEMBL8877361 | 0.75 | SQOR (0.44) | HMGCRTOP1ADORA2AADORA1MAPT | |
| SCHEMBL29419163 | 0.74 | RXRA (0.67) | HMGCRRXRAPRKAA2ADORA2A | |
| SCHEMBL244423 | 0.74 | RXRA (0.67) | HMGCRRXRAPRKAA2ADORA2A | |
| SCHEMBL8876589 | 0.74 | PRKAA2 (0.46) | HMGCRRXRAPRKAA2 | |
| SCHEMBL8952895 | 0.71 | HMGCR (0.55) | HMGCRTOP1ADORA2AADORA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0444533-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |