Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | HMGCR | P04035 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | LDHB | P07195 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878154 | 0.85 | DHODH (0.44) | GCGRHMGCRLDHADHFRDHODH | |
| SCHEMBL8878690 | 0.85 | GCGR (0.46) | GCGRHMGCR | |
| SCHEMBL8878026 | 0.84 | HMGCR (0.46) | GCGRHMGCR | |
| SCHEMBL8879993 | 0.83 | HMGCR (0.49) | GCGRHMGCRDHODH | |
| SCHEMBL8876808 | 0.81 | MEN1 (0.46) | HMGCRMEN1KMT2ADHFRDHODH | |
| SCHEMBL8877998 | 0.81 | HMGCR (0.43) | PTGDR2GCGRHMGCR | |
| SCHEMBL8878198 | 0.78 | DHODH (0.40) | PTGDR2GCGRHMGCRDHODH | |
| SCHEMBL8876825 | 0.78 | PPARA (0.46) | GCGRHMGCRMEN1KMT2ADHFR | |
| SCHEMBL8878856 | 0.77 | GCGR (0.46) | GCGRHMGCR | |
| SCHEMBL8880943 | 0.75 | GCGR (0.45) | GCGRDHFRDHODHALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |