Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.65 |
| ▸ | JAK2 | O60674 | 3/20 | 0.65 |
| ▸ | TYK2 | P29597 | 3/20 | 0.65 |
| ▸ | JAK3 | P52333 | 3/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877161 | 0.86 | JAK2 (0.54) | JAK1JAK2TYK2JAK3PDPK1 | |
| SCHEMBL28258656 | 0.84 | CHEK1 (0.53) | JAK1JAK2TYK2JAK3PRKAB2 | |
| SCHEMBL176936 | 0.84 | PRKAG1 (0.55) | JAK1JAK2TYK2JAK3PDPK1 | |
| SCHEMBL13302523 | 0.83 | PDPK1 (0.53) | JAK1JAK2TYK2JAK3PDPK1 | |
| SCHEMBL15541582 | 0.81 | JAK2 (0.53) | JAK1JAK2TYK2JAK3ITGB3 | |
| SCHEMBL15540985 | 0.81 | MAP2K4 (0.52) | JAK1JAK2TYK2JAK3PRKAB2 | |
| SCHEMBL13386744 | 0.81 | JAK2 (0.50) | JAK1JAK2TYK2JAK3PRKAB2 | |
| SCHEMBL16252829 | 0.81 | MAP2K4 (0.52) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL19208914 | 0.81 | JAK2 (0.59) | JAK1JAK2TYK2JAK3PDPK1 | |
| SCHEMBL15652982 | 0.79 | JAK2 (0.48) | JAK1JAK2TYK2JAK3IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684003-A | GASTROINTESTINAL DISORDERS OR ANTIULCER AGENTS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-11-04 | — | — | US | disclosed |