Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | RGS12 | O14924 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | PTGES | O14684 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878924 | 0.93 | PLA2G2A (0.59) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL8876342 | 0.93 | PLA2G2A (0.59) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL8876716 | 0.91 | PLA2G2A (0.59) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL3246296 | 0.87 | PTGS2 (0.59) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL8877434 | 0.84 | PLA2G2A (0.62) | PLA2G2ATHRATHRBPTGS2 | |
| SCHEMBL8876622 | 0.82 | PLA2G2A (0.60) | PLA2G2ALMNAKMT2APTGESALOX5 | |
| SCHEMBL8876095 | 0.82 | AKR1A1 (0.53) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL3001920 | 0.80 | PLA2G2A (0.67) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL9741283 | 0.79 | PTGES2 (0.57) | MEN1RGS12ALDH1A1LMNACYP1A2 | |
| SCHEMBL7196880 | 0.79 | PTGS2 (0.79) | PLA2G2AMEN1RGS12ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996037467-A1 | N-BENZYLINDOL-3-YL BUTANOIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1996-11-28 | — | — | WO | claimed |
| US-5639780-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA, INC. (CA) | 1997-06-17 | — | — | US | disclosed |