Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878699 | 0.91 | CCR2 (0.46) | CCR2DRD2DRD3HTR2A | |
| SCHEMBL9034053 | 0.89 | CCR2 (0.45) | CCR2DRD2DRD3HTR2A | |
| SCHEMBL8879169 | 0.88 | CCR2 (0.50) | CCR2DRD2DRD4DRD3HTR2A | |
| SCHEMBL8877860 | 0.88 | DRD2 (0.57) | CCR2DRD2DRD4DRD3HTR2A | |
| SCHEMBL8878708 | 0.87 | DRD2 (0.49) | CCR2DRD2DRD3 | |
| SCHEMBL8877910 | 0.86 | CCR2 (0.49) | CCR2DRD2DRD4DRD3HTR2A | |
| SCHEMBL8879189 | 0.86 | CCR2 (0.49) | CCR2DRD2DRD4DRD3HTR2A | |
| SCHEMBL8878411 | 0.86 | CCR2 (0.53) | CCR2DRD2DRD4DRD3DRD1 | |
| SCHEMBL8877476 | 0.86 | CCR2 (0.53) | CCR2DRD2DRD4DRD3DRD1 | |
| SCHEMBL8878677 | 0.83 | CCR2 (0.54) | CCR2DRD2DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |