Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.63 |
| ▸ | HTR1D | P28221 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 9/20 | 0.43 |
| ▸ | DRD4 | P21917 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653994 | 1.00 | HTR1A (0.63) | HTR1AHTR1DHTR2BDRD3DRD4 | |
| SCHEMBL8878091 | 1.00 | HTR1A (0.63) | HTR1AHTR1DHTR2BDRD3DRD4 | |
| SCHEMBL8659591 | 0.90 | HTR1A (0.60) | HTR1AHTR1DHTR2BDRD3DRD4 | |
| SCHEMBL8654532 | 0.89 | HTR1A (0.64) | HTR1AHTR1DHTR2BDRD3DRD4 | |
| SCHEMBL8653841 | 0.80 | HTR1A (0.63) | HTR1AHTR1DHTR2BDRD3DRD4 | |
| SCHEMBL6546383 | 0.78 | HTR1A (1.00) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8065712 | 0.78 | HTR1A (1.00) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL7953632 | 0.76 | HRH4 (0.54) | HTR1AHTR1DDRD3ALDH1A1DRD2 | |
| SCHEMBL8995895 | 0.75 | HTR1A (0.73) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8995900 | 0.74 | HTR1A (0.68) | HTR1AHTR1DHTR2BDRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627177-A | Piperazine derivatives | JOHN WYETH & BROTHER, LTD. (GB) | 1997-05-06 | — | — | US | claimed |