Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.73 |
| ▸ | HTR1D | P28221 | 1/20 | 0.73 |
| ▸ | HTR2B | P41595 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995910 | 0.92 | HTR1A (0.64) | HTR1AHTR1DHTR2BCHRM1KCNQ2 | |
| SCHEMBL8995908 | 0.88 | HTR1A (0.64) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8995900 | 0.87 | HTR1A (0.68) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8065712 | 0.84 | HTR1A (1.00) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL6546383 | 0.84 | HTR1A (1.00) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8653841 | 0.81 | HTR1A (0.63) | HTR1AHTR1DHTR2B | |
| SCHEMBL8653834 | 0.81 | HTR1A (0.63) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8596494 | 0.81 | HTR1A (0.63) | HTR1AHTR1DHTR2B | |
| SCHEMBL8653021 | 0.81 | HTR1A (0.66) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8652998 | 0.80 | HTR1A (0.62) | HTR1AHTR1DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541179-A | Tropon-2-one piperazine carboxamides as serotonergic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-30 | — | — | US | claimed |
| US-5541179-A | Tropon-2-one piperazine carboxamides as serotonergic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |