Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL26669449 | 1.00 | SMN1; SMN2 (0.94) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL5391720 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL16150600 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL31673494 | 0.97 | — | — | |
| Malic Acid SCHEMBL98496 | 0.97 | — | — | |
| Malic Acid SCHEMBL31673489 | 0.97 | — | — | |
| Malic Acid SCHEMBL30036864 | 0.97 | — | — | |
| Malic Acid SCHEMBL856 | 0.97 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL89131 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 368 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119530538-B | Method for realizing efficient and stable enrichment of actinides by regulating nucleation and growth in colloid crystallization process | 同济大学 | 2025-06-10 | — | — | CN | claimed |
| CN-120089701-A | Core-shell structured lithium iron manganese phosphate anode material | 锂源(深圳)科学研究有限公司 | 2025-06-03 | — | — | CN | claimed |
| CN-119707558-A | Mineral nutrition type rice seedling strengthening agent based on seedling raising matrix | 中国水稻研究所 | 2025-03-28 | — | — | CN | claimed |
| CN-119530538-A | Method for realizing efficient and stable enrichment of actinides by regulating nucleation and growth in colloid crystallization process | 同济大学 | 2025-02-28 | — | — | CN | claimed |
| CN-116283182-B | Phosphogypsum, sawing mud and sludge solid-state cooperative regeneration material, and regeneration process and application thereof | 湖北聚海环境科技有限公司 | 2024-12-20 | — | — | CN | claimed |
| CN-118562392-A | Iron-containing silicon carbide substrate polishing solution | 浙江芯秦微电子科技有限公司 | 2024-08-30 | — | — | CN | claimed |
| CN-118472207-A | Modified lithium-rich lithium ferrite lithium supplementing agent coated positive electrode material and preparation method thereof | 中南大学 | 2024-08-09 | — | — | CN | claimed |
| CN-118448686-A | Acid-base amphoteric inorganic-organic hybrid flow battery and preparation method thereof | 安徽恒焺储能科技有限公司 | 2024-08-06 | — | — | CN | claimed |
| CN-117821760-A | Method for photocatalytically and selectively recovering noble metal from sulfur-containing compound organic salt solution | 大连理工大学 | 2024-04-05 | — | — | CN | claimed |
| CN-117617543-A | Fermentation medium for improving color uniformity of eggplant-coated tobacco leaves | 山东中烟工业有限责任公司 | 2024-03-01 | — | — | CN | claimed |
| US-20100135912-A1 | MAGNETOTACTIC BACTERIA MRI POSITIVE CONTRAST ENHANCEMENT AGENT AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-06-03 | — | — | US | claimed |
| US-20100035754-A1 | AGENT FOR IMPROVING ALKALI RESISTANCE OF PLANT AND METHOD FOR IMPROVING ALKALI RESISTANCE OF PLANT | COSMO OIL CO., LTD (JP) | 2010-02-11 | — | — | US | claimed |
| EP-2130435-A1 | AGENT FOR IMPROVING ALKALI RESISTANCE OF PLANT AND METHOD FOR IMPROVING ALKALI RESISTANCE OF PLANT | Cosmo Oil CO., LTD. (JP) | 2009-12-09 | — | — | EP | claimed |
| CN-101541171-A | Agent for improving alkali resistance of plant and method for improving alkali resistance of plant | COSMO OIL CO LTD (JP) | 2009-09-23 | — | — | CN | claimed |
| WO-2007035760-A1 | ENHANCED SOLUBILITY OF PREFORMED CALCIUM CITRATE BY ADDING CITRIC ACID | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-03-29 | — | — | WO | claimed |
| US-20070065542-A1 | Enhanced solubility of preformed calcium citrate by adding citric acid | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-03-22 | — | — | US | claimed |
| US-5520895-A | TREATMENT OF NITROGEN OXIDE AND AMMONIA WITH OXYGEN FOR REDUCTION WITH IRON ON ZEOLITES | MOBIL OIL CORPORATION (US) | 1996-05-28 | — | — | US | claimed |
| US-4975290-A | Method for inhibiting lipid oxidation in foods and compounds useful therefor | ARTZ WILLIAM E (US) | 1990-12-04 | — | — | US | claimed |
| US-4336053-A | INORGANIC ACID | PHILLIPS PETROLEUM COMPANY (US) | 1982-06-22 | — | — | US | claimed |
| US-4056381-A | FROM AN IRON SALT AND AMMONIUM POLYPHOSPHATE | PHILLIPS PETROLEUM COMPANY (US) | 1977-11-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035754-A1 | AGENT FOR IMPROVING ALKALI RESISTANCE OF PLANT AND METHOD FOR IMPROVING ALKALI RESISTANCE OF PLANT | ALAD, ABAT, OAT | SMN1; SMN2 4402/4885SLC22A6 732/4885TET2 438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.