Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723728 | 0.78 | NCF1 (0.44) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL9637930 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL3340171 | 0.73 | ALDH1A1 (0.41) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL4724624 | 0.72 | APP (0.41) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL4724840 | 0.72 | TLR8 (0.39) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL4720683 | 0.70 | TLR8 (0.43) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL641339 | 0.70 | ALDH1A1 (0.47) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL4724189 | 0.69 | ELANE (0.35) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL1998972 | 0.68 | KDM4E (0.42) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL4721803 | 0.68 | ELANE (0.42) | ALDH1A1GLAMAPTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | claimed |
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |