Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 3/20 | 0.53 |
| ▸ | NMT2 | O60551 | 1/20 | 0.45 |
| ▸ | NMT1 | P30419 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264043 | 0.82 | HTR2C (0.60) | HTR6HTR2CADRB2APPHTR1A | |
| Hydrochloric Acid SCHEMBL11847902 | 0.81 | HTR2C (0.59) | HTR6HTR2CADRB2APPHTR1D | |
| SCHEMBL8876508 | 0.79 | HTR6 (0.55) | HTR6HTR2CADRB2APPNMT2 | |
| SCHEMBL6956308 | 0.79 | HTR6 (0.57) | HTR6HTR2CADRB2APPNMT2 | |
| SCHEMBL2781509 | 0.77 | HTR2C (0.62) | HTR6HTR2CADRB2APPNMT2 | |
| SCHEMBL8878109 | 0.77 | SLC6A4 (0.57) | HTR6HTR1AHTR7HTR2A | |
| SCHEMBL7003242 | 0.77 | SLC6A4 (0.57) | HTR6HTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL14775067 | 0.75 | HTR2C (0.42) | HTR2CHTR1A | |
| SCHEMBL5705128 | 0.75 | HTR2C (0.56) | HTR6HTR2CADRB2APPHTR1D | |
| SCHEMBL25079811 | 0.75 | HTR2C (0.58) | HTR6HTR2CADRB2APPHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| CN-1133840-A | Indolepiperidine derivatives | MERCK PATENT GMBH (DE) | 1996-10-23 | — | — | CN | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |