Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | GABRP | O00591 | 2/20 | 0.47 |
| ▸ | GABRD | O14764 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.47 |
| ▸ | GABRE | P78334 | 2/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18474133 | 0.88 | MTNR1A (0.49) | HTR6HTR2CHTR1ASLC6A4KMT2A | |
| SCHEMBL2264043 | 0.85 | HTR2C (0.60) | HTR6HTR2CADRB2APPHTR1A | |
| Hydrochloric Acid SCHEMBL11847902 | 0.84 | HTR2C (0.59) | HTR6HTR2CADRB2APPHTR1A | |
| SCHEMBL5705128 | 0.83 | HTR2C (0.56) | HTR6HTR2CADRB2APPHTR1A | |
| SCHEMBL8819815 | 0.80 | SLC6A4 (0.56) | HTR6HTR1ASLC6A4HTR2A | |
| SCHEMBL18441311 | 0.79 | HTR1B (0.53) | HTR2CHTR1ASLC6A4KMT2AHTR2A | |
| SCHEMBL8879367 | 0.79 | HTR6 (0.57) | HTR6HTR2CADRB2APPGABRP | |
| SCHEMBL6956308 | 0.79 | HTR6 (0.57) | HTR6HTR2CADRB2APPGABRP | |
| SCHEMBL18441329 | 0.78 | MTNR1A (0.46) | HTR6HTR1ASLC6A4KMT2AHTR2A | |
| SCHEMBL7483859 | 0.78 | APP (0.45) | HTR6HTR2CADRB2APPGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |